Relation of modifiable lifestyle and mood factors to subjective cognitive concerns among participants and their study partners in the A4 screen data

Background Subjective cognitive decline (SCD) is associated with future decline, elevated amyloid levels, and non-specific variables, including mood. Participants often endorse higher concerns than their study partners (SPs), raising the possibility that participant complaints reflect multiple factors, mood, lifestyle status. To determine predictive value of modifiable we examined relation between SCD, habits, amyloid, mood among cognitively unimpaired older adults from a multi-site secondary prevention trial (A4 screen data). Method were 6943 individuals A4 assessed pre-randomization [mean(SD): age = 71.6(4.9), education 16.4(3.0); 58% women, 95% non-Hispanic or Latino, 90% white)]. Using descriptive analyses linear regression models, whether status (amyloid+: n 1329/4492) self-reported (Geriatric Depression Scale [GDS]) habits (exercise, sleep) predicted subjective (CFI; participant- SP-reported). Result endorsed healthy (mean hours aerobic exercise/week 2.9; mean sleep/night 7.1), minimal symptoms GDS 1.1), SPs (t(5996) -25.08, p<.001). Lower (t 29.49, p<.001), 5.75, lower -3.92, p<.001) on CFI, additive exercise -2.90, p .004) sleep duration -2.12, .035); however, only participant-reported 12.90, 6.54, SP concerns. Adding to model in subset, all predictors for remained except sleep, while 4.59, 11.53, 4.72, Conclusion Cognitively participants CFI compared SPs. Participant (age, education, status, exercise, sleep), age, may be more aware early changes reflecting various personal report specific due burden. These findings expand understanding how factors (e.g., biomarkers, habits) contribute differently concerns, which inform research recruitment clinical care.